Approximately 1 in 5 dogs may be affected by urinary sphincter mechanism incompetence (USMI).


What is canine urinary mechanism incompetence (USMI)?

Canine urinary incontinence results from weakened muscles of the urethral sphincter, the tube that runs from the bladder to the outside. These weakened muscles allow urine to leak out, often while the dog is lying down or sleeping.

What are the symptoms of urinary incontinence in dogs?

  • Dripping or leaking urine
  • Excessive licking of the genital area
  • Red and irritated skin around the genital area
  • Needing to go more frequently than normal
  • Wetting the bed or sleeping area
  • Urinating inappropriately in the house

Fortunately, while frustrating at first, canine urinary incontinence may be controlled with PROIN, a safe and effective FDA-approved chewable tablet.

Get your dog to the veterinarian today to find out if proin can help.

Urinary Bladder

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What types of dogs are most at risk?

Canine incontinence can affect dogs of any age, size, breed, or gender. However, this problem is more commonly associated with:

  • Middle-aged to older spayed females
  • Cocker spaniels, springer spaniels, Doberman Pinschers, Old English Sheepdogs, Irish setters, German shepherds, boxers, rottweilers, giant schnauzers, and Weimaraners 2
  • Dogs with docked tails3
  • Overweight or obese dogs
  • Larger dogs (over 45 lbs.)4

Does your dog have USMI?

Only your veterinarian can definitively diagnose canine incontinence. If you suspect that your beloved pal may have lost control of her bladder, contact your veterinarian today.

Along with a physical exam, your veterinarian will likely want to discuss your pet's health and behavior. Some of the questions you may be asked include:

  • When did you first notice the urinary incontinence?
  • How often are you finding spots and where are they?
  • Is the leakage occurring during sleep or with activity?
  • Does your dog seem to be drinking more than normal?
  • Has your dog had a change in diet or medications?

Your veterinarian will also likely conduct a urinalysis. This will help identify any infections that could be treated with antibiotics. Depending on the results of the urinalysis and physical exam, your veterinarian may also perform additional tests such as a urine culture, blood work, radiographs, X-rays, and/or ultrasounds.

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IMPORTANT SAFETY INFORMATION: For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately. The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse. Instances of dogs chewing through closed vials of PROIN and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN Chewable tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN Chewable tablets. PROIN may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. The safe use of PROIN in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions or visit
Refer to the full prescribing information for complete details. NADA#141-324 Approved by FDA
PROIN is a registered trademark of Pegasus Laboratories, Inc.